Magnus Olofsson´s research

The World Health Organization (WHO) recognizes the increasing antimicrobial resistance of pathogenic bacteria (AMR) as a global challenge. REF  The increase in AMR results in a widening gap between the supply and demand of effective antibiotics. In the future, common infections (such as pneumonia) will most likely call for antibiotics that are expensive, difficult to administer, or cause more side effects than the preparations in current use. Life-threatening infections (such as blood-poisoning) will probably become very difficult to treat asantibiotics fall short of covering pathogens even when given in combination and in high doses.

The WHO states that microbiological surveillance is a prerequisite in identifying and containing resistant strains of bacteria. REF Internationally, there are several institutions that systematically assemble surveillance data from microbiological laboratories working in conjunction with hospitals. Even so, trends in AMR development are difficult to interpret when based solely on clinical data given the broad patient mix. Too much detail Local screening studies are considered necessary to enhance precision.REF

Three main characteristics good Jdetermine what species of bacteria deserve more extensive monitoring given their propensity for AMR development: (1) the tendency to spread in hospital environments, (2) the capacity to cause more serious disease than their non-resistant counterparts and (3) the tendency to acquire more, or even multiple, resistance mechanisms with time. The European Centre for Disease Prevention and Control (ECDC) recognizes methicillin-resistant Staphylococcus aureus (MRSA) as one such key pathogen connected with AMR. REF

Nursing homes have been implicated as significant disease reservoirs in the past, but to date only a few comprehensive screening studies have been done within this clinical setting in Europe

Magnus thesis:
Microbiological Surveillance in Primary Health Care: New Aspects of Antimicrobial Resistance and Molecular Epidemiology in an Ageing Population

 

Contact Magnus: magnus.olofsson@regionostergotland.se