Kaveh defended his thesis September 12 2013.
Intraepidermal nerve fibre density is associated with weight
Background and Aims
Intraepidermal nerve fibre density (IENFD) quantification is regarded to be a sensitive and specific measure of small nerve fibre dysfunction and IENFD loss is an early feature in glucose dysregulation. Our aims were to study IENFD in individuals with normal glucose tolerance (NGT), impaired glucose tolerance (IGT) and type 2 diabetes (T2D) and to study if IENFDwas associated to metabolic traits, e.g. obesity and dyslipidemia.
Participants were recruited from the population-based Västerbotten Intervention Program; Nerve conduction studies (NCS) were performed and standardized to z-scores representing the nerve function in the leg. Neuropathy disability score was used to evaluate neuropathic signs and thermal threshold tests were performed to assess small nerve fibre function. Skin biopsieswere performed using a3-mm punch taken 10 cm proximal to the lateral malleolus. Light microscopy was used to identify nerve fibres in thin sections (5 µm) according to a standardized protocol.
It is expected that the IENFD differs significantly betweenindividuals with normal glucose tolerance, impaired glucose tolerance and individuals with type 2 diabetes. There might be associations between IENFD and metabolic traits other than hyperglycemia. Biopsies for IENFD quantification in thin sections can prove to be a simple useful method for assessing small nerve fibre neuropathy in individuals with diabetes.
Kavehs e-mail: email@example.com